Horizon
Horizon
Trial and Error #S40E07
It was the simplest idea but one with enormous potential. If a gene is defective in the human body, just replace it with one that works properly. Gene therapy would mean that genetic disorders would become a thing of the past. Cancer would be cured, as would cystic fibrosis and hundreds of other genetic illnesses. Scientists were justifiably excited about the idea but, this enthusiasm that would end up costing one young man his life. Jesse Gelsinger was born with a liver disorder, a rare condition called ornithine transcarbamylase (OTC) deficiency that stops the liver metabolising ammonia. People with the disease can suffer from brain damage or coma. At its most extreme the illness is fatal. Jesse was lucky, able to lead a fairly normal life although he had a daily cocktail of drugs to control his condition. Jesse wanted to help others. When he was offered a chance to take part in a medical trial to test the safety of using gene therapy for OTC deficiency, he was keen to participate. He knew this was not a cure for his condition but that, by volunteering he might be able to help others in the future. Although the concept of gene therapy is simple, the practice of administering the treatment is much more difficult. In order to replace defective genes, doctors must get working ones into the body and to the place where they are needed.
Episode 7 of Season 40 from Horizon — available to stream in HD on any device.
Comments & Discussions
Join the conversation
Sign in to leave a comment
No comments yet
Be the first to share your thoughts!
Recommended
Because you liked Horizon
Mysteries Unearthed with Danny Trejo
Mysteries Unearthed with Danny Trejo
Grand Designs: House of the Year
Grand Designs: House of the Year
Million Dollar Beach House
Million Dollar Beach House
Words + Music
Words + Music
The End of an Era
The End of an Era
Killer Relationship with Faith Jenkins
Killer Relationship with Faith Jenkins
Wild Wild Country
Wild Wild Country
Born to Be Wild
Born to Be Wild
Den Sorte Svane
The Black Swan
Titanic Sinks Tonight
Titanic Sinks Tonight
Explore Content
Search for movies, TV shows, collections, manga, or people
Trending Now